Discovery of a gene conferring multiple-aminoglycoside resistance in Escherichia coli.
نویسندگان
چکیده
Bovine-origin Escherichia coli isolates were tested for resistance phenotypes using a disk diffusion assay and for resistance genotypes using a DNA microarray. An isolate with gentamicin and amikacin resistance but with no corresponding genes detected yielded a 1,056-bp DNA sequence with the closest homologues for its inferred protein sequence among a family of 16S rRNA methyltransferase enzymes. These enzymes confer high-level aminoglycoside resistance and have only recently been described in Gram-negative bacteria.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 54 6 شماره
صفحات -
تاریخ انتشار 2010